I think a lot of this will depend on the system you are running. I've never used Roll20 but have a fair bit of time and money invested in FG, and got Foundry to look into the Runequest development. While there I looked at what other game systems where available, and I picked up Warhammer (I already have a load of CoC on FG which I think works really well). I've installed some modules and done very minimal config, nothing I would class as coding, and I think apart from creating maps and adventures, I'm ready to go.
So I'm really hoping that Runequest is as polished, and contains a similar level of automation.