Hey, all:
Matt Helms, gamer for 27 years, Call of Cthulhu gamer for 22 years, and Chaosium freelance editor for a few years now.
BRP is the system I always go back to. The system's deceptive simplicity has handled everything from long-running campaigns to experimental one-shots with grace and ease. With it, I've run everything from straight-up Cthulhu to "Kung Fu" in Outer Space. Now with the new BRP core book, I will probably be using BRP for all my games.
-Matt