Being most recently immersed in BROSR style play and the attendant conversations thereof, the primary story model for one style of play (label it what you will) is “pulp fiction” (see Jeffro Johnson’s blog and book “Appendix N.”)
RuneQuest in its classical form uses the myth/legend as story model so play tends to be very different.
The primary driver of the difference, imo, is how magic is treated in the game. 5e made magic ubiquitous and morphed into a weird little d20 simulacrum of RuneQuest. Most of the BX crowd are playing LFG whether they realize it or not where Low Fantasy Gaming is anthropocentric with restricted magic.
As an edit, an example of this treatment of magic is the difference between RQG and Call of Cthulhu.