The problem with playing four-color superheroes with a mechanistic system like BRP is the huge range of powers available, from the simply highly skilled, The Dark Knight, to near-gods, like the Man of Steel. For this wide range narrative, systems, like HeroQuest or Atomic Sock Monkey's Truth And Justice give you more wiggle-room.
Because, you could, and eventually, see an issue where Spiderman, through some amazing, narrative contrivance, defeats Galactus.
Though I imagine BRP would work for most Gamers, who are fine with not playing characters who can reverse time by circling the earth at FTL speed.